Trends in mortality rates associated with multiple myeloma in the United States, 1999-2023.

ABSTRACT:

Background

Despite substantial therapeutic advances, multiple myeloma (MM) continues to be an important contributor to cancer-related mortality in the United States. Understanding long-term mortality patterns is essential for guiding equitable clinical and public health strategies.

Methods

We used CDC WONDER mortality data from 1999-2023 to evaluate MM-related deaths among U.S. adults aged ≥25 years. Age-adjusted mortality rates (AAMRs) were calculated using direct standardization to the 2000 U.S. population. Temporal trends were examined using Joinpoint regression to estimate annual percent changes (APCs) and identify significant shifts over time. Analyses were stratified by age, sex, race/ethnicity, state, and urbanization level.

Results

Nationally, MM mortality dec

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12740889 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature