CSF-flow prior and after spinal tap test in patients with idiopathic normal pressure hydrocephalus-an exploratory study using real-time phase-contrast MRI.

ABSTRACT:

Background

Neuroimaging plays a key role in the diagnostic workup of patients with idiopathic normal pressure hydrocephalus (iNPH). A flow void in the aqueduct - indicating increased cerebrospinal fluid (CSF) velocity - is a common, but unspecific finding. Aim of this study was to investigate CSF-flow characteristics in iNPH patients before and after spinal tap test (STT) using novel, real-time phase-contrast magnetic resonance imaging (RT-PC MRI).

Methods

We included consecutive patients with clinical signs of iNPH being electively admitted for diagnostic workup, including neurological examination, conventional MRI and STT. RT-PC MRI and clinical examination were performed before and within 24 h after STT. CSF-flow volumes were determined at five regions in the inner and ou

SUBMITTER: Dierksen F 

PROVIDER: S-EPMC12740890 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature