Identification and validation of ubiquitination-associated genes of senile osteoporosis based on bioinformatics analysis.

ABSTRACT:

Background

Senile osteoporosis (SOP) is linked to the ubiquitination process, with dysregulation of ubiquitin-mediated protein turnover disrupting bone remodeling and resulting in decreased bone mineral density (BMD). This study aimed to identify biomarkers related to ubiquitination in SOP and explore their molecular regulatory mechanisms.

Methods

Transcriptomic data of SOP samples (categorized by high and low BMD) were obtained from public databases. Differential expression analysis, protein-protein interaction networks, and the CytoHubba plugin (using Maximum Neighborhood Component and degree algorithms) were utilized, alongside the Least Absolute Shrinkage and Selection Operator, to identify ubiquitination-related genes (URGs) as potential SOP biomarkers. The diagnostic p

SUBMITTER: Cheng X 

PROVIDER: S-EPMC12740899 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature