Assessment of levothyroxine therapy adequacy in low-risk differentiated thyroid carcinoma: a multicenter cohort study.

ABSTRACT:

Objective

This study aimed to evaluate the adequacy of levothyroxine therapy, assessed by serum thyrotropin (TSH) levels, in patients with low-risk differentiated thyroid carcinoma (DTC).

Methods

We conducted a multicenter, retrospective cohort study including patients with low-risk DTC. Dynamic risk stratification was performed 12 months after initial treatment and at the last follow-up visit according to the 2015 American Thyroid Association (ATA) guidelines. Patients were categorized based on treatment response as excellent, indeterminate, biochemical incomplete, and structural incomplete. Levothyroxine adequacy was determined according to ATA-recommended TSH target values.

Results

A total of 1016 patients (median age, 48 years; 80.7% women; 91.4% papillary thyroid

SUBMITTER: Diez JJ 

PROVIDER: S-EPMC12740901 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature