Tobacco-specific nitrosamine exposure from electronic cigarettes versus combustible cigarettes: an <i>ad hoc</i> analysis within a systematic review of emission studies.

ABSTRACT:

Introduction

Tobacco-specific nitrosamines (TSNAs), particularly 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN), have been shown to be among the most potent carcinogens found in tobacco products. With the rapid adoption of electronic cigarettes (e-cigarettes) as alternatives to combustible cigarettes, understanding the extent of TSNA exposure has become central to oncology practice and risk communication.

Methods

This ad hoc analysis, based on studies identified from a systematic review of e-cigarette emissions, synthesized evidence from 13 emission studies that directly compared NNK and NNN levels between e-cigarette aerosols and cigarette smoke. Eligible studies were identified through comprehensive database searches (MEDLINE, Embase,

SUBMITTER: Miguel RTD 

PROVIDER: S-EPMC12740905 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature