Estimated glucose disposal rate and cardiovascular disease risk: a meta-analysis of cohort studies.

ABSTRACT:

Background

Insulin resistance (IR) is a key cardiovascular disease (CVD) risk factor. The estimated glucose disposal rate (eGDR) is a reliable IR marker linked to CVD risk. This study is the first extensive meta-analysis of this correlation in a general population free from baseline CVD.

Methods

We searched electronic databases such as PubMed, Web of Science and Embase for cohort studies reporting eGDR and CVD risk. Studies included adults without baseline CVD, measured eGDR at baseline, and reported hazard ratio (HR) [95% confidence interval (CI)]. The combined HR and its 95% CI were determined through the application of random or fixed effects models. Meta-regression with robust error was utilized to depict the nonlinear dose-response relationship.

Results

Twelve co

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12740917 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature