Identifying and validating hypoxia- and metabolism-related hub genes and cell communication in atherosclerosis.

ABSTRACT:

Background

Atherosclerosis (AS) is a multifactorial disorder characterized by plaque formation, with hypoxia and metabolic pathways playing central roles in its pathogenesis. However, the differentially expressed metabolism-hypoxia-related genes (DE-MH-RGs) contributing to AS remain largely undefined. This study aimed to characterize DE-MH-RGs to uncover their potential regulatory mechanisms in AS.

Results

Single-cell sequencing data, AS-related datasets, 200 hypoxia-related genes (HRGs), and 2,752 metabolism-related genes (MRGs) were employed for analysis. Single-cell sequencing identified distinct cell subpopulations, and differential gene expression was assessed between the AS and normal groups in GSE100927. DE-MH-RGs were determined by intersecting differentially express

SUBMITTER: Hao L 

PROVIDER: S-EPMC12740931 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature