The electrophysiology of ventricular cell pairs.

ABSTRACT: Modern cardiac electrophysiology is largely focused on global electrical properties of tissue, frequently assessed by extracellular electrical recordings or optical mapping, whereas studies on the microscopic nature of action potential conduction are more rare, though fundamental to understand the whole-heart behavior. The electrophysiological dynamics of two ventricular myocytes electrically connected via gap junctions is the simplest conceivable model to study the laws governing the conduction of the electrical impulse within the heart ventricles. Since the enzymatic dispersion of cardiac cells has made it possible to isolate and investigate cardiac cell pairs directly, additional techniques have been introduced to investigate the problem, including coupling clamp, dynamic clamp, and num

SUBMITTER: Zaniboni M 

PROVIDER: S-EPMC12740972 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature