FoxO1 Responses to Chronic Oxidative Stress to Participate in Age-Related Osteoporosis by Depriving β-Catenin From TCF7.

ABSTRACT: The increasing prevalence of age-related osteoporosis has emerged as a critical public health issue in the context of the globally aging population. Chronic oxidative stress, induced by excessive reactive oxygen species (ROS) associated with aging, is a critical factor underlying the development of osteoporosis in elderly individuals and a diminished capacity for bone formation and osteogenic differentiation. However, the mechanism underlying age-related osteoporosis remains unclear. MACF1 (microtubule actin crosslinking factor 1) is an essential factor that regulates bone formation and development, and exhibits reduced expression as humans age. In this study, we used MACF1 conditional knockout (MACF1-cKO) mice as a premature aging model and found that MACF1-cKO mice exhibited chronic oxid

SUBMITTER: Su P 

PROVIDER: S-EPMC12740996 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature