Clinical correlation of anti-desmoglein antibody dynamics in pemphigus treated with rituximab.

ABSTRACT: Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are blistering disorders mediated predominantly by IgG1 and IgG4 antibodies directed towards desmoglein (Dsg)1 and/or 3. The anti-CD20 monoclonal antibody rituximab is a highly effective treatment for PV, although less is known regarding its efficacy in the treatment of PF and the dynamics of anti-Dsg1 IgG subclasses post rituximab treatment. We therefore investigated clinical outcomes and anti-Dsg antibody dynamics in 105 pemphigus patients (89 with PV, 16 with PF) treated with rituximab. Similar treatment responses were observed in PV and PF, although there were significant differences in anti-Dsg antibody dynamics post treatment, with a greater reduction of anti-Dsg1 in anti-Dsg1 positive PV than in PF which corresponded to a reductio

SUBMITTER: Naidu V 

PROVIDER: S-EPMC12741074 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature