Application of thromboelastogram and coagulation function in evaluating coagulation status of pregnant women across different trimesters.

ABSTRACT:

Background

Pregnancy induces a hypercoagulable state to prevent hemorrhage during delivery, but it also increases the risk of thrombotic events and postpartum hemorrhage. Monitoring coagulation changes is essential to ensure maternal and fetal health. Thromboelastography (TEG), which provides a detailed assessment of the coagulation cascade, remains underutilized across all stages of pregnancy.

Methods

This retrospective study included 92 pregnant women grouped by trimester (30 in the first, 34 in the second, and 28 in the third), and 30 non-pregnant women as controls. Standard coagulation metrics [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB)] and TEG parameters (R, K, α-angle, MA) were measured and compa

SUBMITTER: Li J 

PROVIDER: S-EPMC12741125 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature