Exploring HSP90α and hs-CRP using AI models to predict prognosis in advanced hepatocellular carcinoma treated with PD-1 inhibitors and targeted therapy.

ABSTRACT:

Objective

This study investigates the roles of heat shock protein 90α (HSP90α) and high-sensitivity C-reactive protein (hs-CRP) in the progression and prognosis of advanced hepatocellular carcinoma (HCC) patients undergoing immunotherapy. By integrating these biomarkers with artificial intelligence (AI), we aim to elucidate the complex interactions between tumor stress, immune responses, and tumor progression.

Methods

This retrospective analysis includes 644 patients with advanced HCC who received PD-1 inhibitors and targeted therapy across 3 tertiary hospitals in China from 2016 to 2023. The patients were randomly divided into training (70%) and validation (30%) sets. Independent prognostic factors for overall survival (OS) were identified using LASSO and stepwise Cox regre

SUBMITTER: Wu ZY 

PROVIDER: S-EPMC12741144 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature