Global Burden of Pelvic Organ Prolapse, 1990-2021: An Ecological Study and Mendelian Randomization Analysis.

ABSTRACT:

Background and aims

Pelvic organ prolapse (POP) represents a major global health challenge for women. This study systematically analyzed the global disease burden of POP and associated risk factors from 1990 to 2021, including projections of future trends.

Methods

The data were derived from the Global Burden of Disease (GBD) 2021 database and genome-wide association studies (GWAS). Additionally, we combined the age-period-cohort (APC) model with the autoregressive integrated moving average (ARIMA) model to analyze the driving factors and project future disease burden trends. Furthermore, we performed a two-sample Mendelian randomization (MR) analysis to assess whether genetic liability to selected traits is associated with POP.

Results

From 1990 to 2021, the global cr

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12741253 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature