Risk factors for anticoagulant-related bleeding in cancer: traditional and cancer-specific factors.

ABSTRACT: Managing anticoagulant therapy in cancer-associated venous thromboembolism (VTE) is challenging due to risks of recurrent VTE and anticoagulant-related bleeding. Existing clinical risk models for bleeding are limited by discriminatory ability in patients with cancer, perhaps due to the omission of cancer-specific risk factors for bleeding. This study estimated the associations of traditional and cancer-specific risk factors with bleeding requiring hospitalization in patients with cancer-associated VTE prescribed anticoagulant therapy. We conducted a retrospective cohort study using the Veterans Health Administration database to identify patients with cancer-associated VTE between 2012 and 2020. Cancer-associated VTE was defined by diagnostic International Classification of Diseases codes a

SUBMITTER: Loncharich A 

PROVIDER: S-EPMC12741364 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature