Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial.

ABSTRACT:

Background

Varicose veins affect 25% to 40% of adults, with higher prevalence in older populations. Although Vitis vinifera seed extract (VVSE) can alleviate symptoms of venous insufficiency, its effects on venous reflux remain uncertain. We hypothesized that oral VVSE supplementation would significantly reduce venous reflux time compared with lifestyle modifications alone in patients with lower extremity varicose veins.

Methods

This prospective, open-label, randomized controlled trial enrolled adults aged 19 to 80 years with varicose veins and venous reflux confirmed by Doppler ultrasound (≥0.5 seconds in superficial veins or ≥1 second in deep veins). Patients were provided oral VVSE (150 mg twice daily) plus therapeutic lifestyle changes or therapeutic lifestyle changes al

SUBMITTER: Bae S 

PROVIDER: S-EPMC12741370 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature