Hagfish olfactory repertoire illuminates lineage-specific diversification of olfaction in basal vertebrates.

ABSTRACT: Chemosensory receptors for olfaction of vertebrates have undergone remarkable diversification, but the ancestral repertoire remains incompletely understood. Here, we present a comprehensive genome-wide survey and gene expression analyses of the olfactory repertoire in hagfish, a cyclostome group that typically inhabits the deep sea with a well-developed olfactory system. We identified 48 olfactory receptors (ORs), two vomeronasal type 1 receptors (V1Rs), 135 typical vomeronasal type 2 receptors (V2Rs), and no trace amine-associated receptors (TAARs) in the inshore hagfish, Eptatretus burgeri. Expression analysis confirmed that most of these genes are expressed predominantly in the olfactory organ, supporting that these receptors are functional. Our findings suggest that typical olfa

SUBMITTER: Kariyayama H 

PROVIDER: S-EPMC12741414 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature