Gingival Crevicular Fluid Proteomic Shift: From Gingivitis to Periodontitis.

ABSTRACT:

Introduction and aims

Gingivitis is a reversible, mild inflammation, whereas periodontitis is a chronic condition with irreversible tissue destruction. Despite the widespread use of clinical indicators, their lack of molecular specificity limits mechanistic diagnosis. Gingival crevicular fluid, a noninvasive medium reflecting localized immune activity, has been insufficiently explored in proteomic studies to distinguish gingivitis from periodontitis. This study revealed quantitative proteomics and network analysis to identify distinct molecular characteristics differentiating the two conditions.

Methods

We analysed 72 gingival crevicular fluid samples from healthy, gingivitis, and periodontitis groups using liquid chromatography-mass spectrometry and integrated bioinformatic

SUBMITTER: Mok JH 

PROVIDER: S-EPMC12741460 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature