Frequency-Dependent Diffusion-Relaxation Distribution MRI: Scan-Rescan Reproducibility Ex Vivo and Caveats.

ABSTRACT: Frequency-dependent diffusion-relaxation distribution MRI provides information beyond the traditional voxel-averaged metric that may better characterize the microstructural features of biological tissue. Frequency-dependent multidimensional ( ω$$ \omega $$ MD) MRI reproducibility has been established in clinical settings, but has yet to be thoroughly evaluated under preclinical conditions, where superior hardware and modulated gradient waveforms enhance its performance. In this study, we investigate the reproducibility of ω$$ \omega $$ MD-MRI using a micro-imaging system to investigate ex vivo mouse brains. Notably, the estimated signal fractions of intra-voxel spectral components in the ω$$ \omega $$ MD-MRI distribution, corresponding to white and gray matter, along with the frequency-dep

SUBMITTER: Or PSK 

PROVIDER: S-EPMC12741536 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature