Monoamine Loss and Functional Connectivity Alterations in Patients With Parkinson's Disease and Depression.

ABSTRACT:

Background

The pathophysiology and neural substrates of depression in Parkinson's disease remain unclear. It has been associated with dysregulation of the monoaminergic systems. Furthermore, functional abnormalities within the mesolimbic-basal ganglia reward circuit may be involved in the pathogenesis of Parkinson's disease-related depression.

Objectives

We aimed to investigate monoaminergic deficits and the corresponding changes within the striatum-mesolimbic circuitry in patients with Parkinson's disease and depression.

Methods

This study included eight depressed and 18 non-depressed patients with Parkinson's disease and 28 matched healthy controls. We simultaneously obtained ¹⁸F-fluoropropyl-dihydrotetrabenazine positron emission tomography (¹⁸

SUBMITTER: Xu BL 

PROVIDER: S-EPMC12741543 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature