The associations between midlife neighborhood socioeconomic conditions and late-life cognitive trajectories: The mediating roles of hemoglobin A1c and blood pressure.

ABSTRACT:

Introduction

Neighborhood socioeconomic conditions (NSECs) are recognized determinants of late-life cognitive health; mechanisms remain unclear but may include cardiometabolic factors, which have been linked to cognitive decline and dementia.

Methods

Causal mediation analyses were conducted to examine whether cardiometabolic factors (glycated hemoglobin-HbA1c, diabetes, blood pressure, hypertension) each mediate the association between midlife NSECs (tract-level disadvantage and affluence) and late-life cognitive trajectories (maintainers, minor decliners, major decliners) in a nationally representative sample of adults aged 50+ (N = 4304).

Results

Worse midlife NSECs were associated with an increased risk of minor and major cognitive decline, as well as elevated and

SUBMITTER: Cheng GJ 

PROVIDER: S-EPMC12741882 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature