Cerebrospinal fluid proteome alterations related to depressive symptoms in cognitive decline and Alzheimer's disease.

ABSTRACT:

Background

Depressive symptoms are common in cognitive decline and Alzheimer's disease (AD), but their underlying pathology remains poorly understood. We aimed to investigate the pathophysiology of depressive symptoms in the context of AD.

Methods

Individuals with normal cognition (NC), mild cognitive impairment (MCI), or mild AD dementia from two independent, large cohorts were included. Untargeted mass spectrometry-based cerebrospinal fluid (CSF) proteomics, regression analyses, and pathway-enrichment analyses were applied.

Results

A total of 688 individuals (223 NC, 190 MCI, and 275 AD dementia) were included. The levels of 57 out of 946 robustly quantified CSF proteins were associated with depressive symptoms consistently across both cohorts. These proteins were e

SUBMITTER: Rabl M 

PROVIDER: S-EPMC12741918 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature