Mesial temporal tau pathology impacts basal forebrain degeneration in early Alzheimer's disease.

ABSTRACT:

Introduction

The cholinergic basal forebrain system, particularly the nucleus basalis of Meynert (Ch4), is selectively vulnerable to amyloid beta (Aβ) and tau in Alzheimer's disease (AD). Their interplay may be a critical driver of AD progression, but remains poorly understood.

Methods

Data from 779 older individuals in the Australian Imaging, Biomarker, and Lifestyle study were analyzed, all of whom underwent ¹⁸F-NAV4694 Aβ and ¹⁸F-MK6240 tau positron emission tomography and magnetic resonance imaging.

Results

The co-occurrence of Aβ and mesial-temporal (MTL) tau pathologies was associated with reduced Ch4 volumes in cognitively unimpaired individuals. MTL tau burden was associated with Ch4 volumes exclusively in cognitively unimpaired individua

SUBMITTER: Xia Y 

PROVIDER: S-EPMC12741919 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature