The Disrupted Bidirectional Regulation and Coupling of Resting-State Blood Pressure and Heartbeat in Hypertension.

ABSTRACT: The bidirectional non-linear communication between blood pressure (BP) and heartbeat is critical to cardiovascular homeostasis, which remains poorly understood, especially under hypertensive conditions. We implemented transfer entropy (TE), an information-theoretic measure of directional coupling, to characterize such bidirectional coupling between BP and heartbeat and its relationships to arterial stiffness and walking performance in older adults. A total of 493 older adults (201 normotensive (NTN), 168 controlled-hypertensive (controlled-HTN), and 124 uncontrolled-HTN) completed simultaneous recordings of resting-state beat-to-beat BP and R-R interval for ≥ 10 min. The TE from BP to RR (i.e., BP-RR) and from RR to BP (RR-BP) was quantified. Participants then completed the assessments of

SUBMITTER: Jiang X 

PROVIDER: S-EPMC12741931 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature