Associations between cerebral blood transit time, amyloid-β pathology and cognitive decline in non-demented older adults.

ABSTRACT:

Introduction

The contribution of cerebrovascular hemodynamic disturbances to Alzheimer's disease (AD) remains unclear. Using time-shift analysis of blood-oxygenation-level-dependent (BOLD) signals, we explored associations between cerebral blood transit time, amyloid beta (Aβ) pathology, and cognition.

Methods

We included 131 non-demented individuals from the Alzheimer's Disease Neuroimaging Initiative. Three transit metrics - termed Lag_ICA-SSS, Lag_ICA-global, and Lag_global-SSS - were derived from BOLD time lags between the internal carotid artery (ICA), superior sagittal sinus (SSS), and global signal. Associations between transit metrics, Aβ burden, and cognition were investigated through cross-sectional and longitudinal analyses.

Result

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12741934 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature