Comparative dosimetric evaluation of 68Ga-PSMA and 18F-Choline PET/CT imaging in prostate cancer: implications for radiation safety and SUVmax correlation.

ABSTRACT:

Background

Comparative patient dosimetry for diagnostic PET/CT can guide radiation-safety procedures and tracer selection in prostate cancer. We compared [^68Ga]Ga-PSMA-11 and ^18F-choline PET/CT and examined whether kidney SUVmax predicts patient effective dose (ED).

Methods

Prospective single-center study of consecutive men undergoing clinically indicated PET/CT: 70 ^68Ga-PSMA-11 and 70 ^18F-choline examinations (Jan 2022-Dec 2023). Dose-rate measurements were recorded at the injection site and at 1 m, immediately post-injection and at 1 h. ED was derived from literature-based tracer coefficients (h_PSMA-11 = 0.0169 mSv/MBq; h_F-choline = 0.0173 mSv/MBq). Kidney SUVmax was extracted in a subset (n = 40 per tracer) to test ED-SUVmax associations (Pearson's r).

SUBMITTER: Kaafarani HR 

PROVIDER: S-EPMC12741963 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature