Unravelling the exposome of severe exacerbations of obstructive respiratory diseases in France.

ABSTRACT:

Introduction

Understanding the influence of environmental and socioeconomic factors, collectively known as the exposome, on severe exacerbation risks in chronic obstructive pulmonary disease (COPD) and asthma is crucial for enhancing patient care.

Methods

We assessed the impact of the exposome on COPD and asthma severe exacerbations in France between 2018 and 2022, combining data from the French National Hospital Discharge Programme de Médicalisation des Systèmes d'Information database and open data for multiple environmental exposition. Using a retrospective matched case-control design, 473 990 patients with COPD and 187 332 patients with asthma were matched for sex, birth year and date of first hospitalisation. Conditional logistic regressions were performed to quantify OR

SUBMITTER: Tcherakian C 

PROVIDER: S-EPMC12742079 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature