Effect size and event rate estimation in neurocritical care randomised clinical trials: a protocol for a systematic review.

ABSTRACT:

Introduction

Effect size and event rate estimation is necessary for sample size calculation in randomised clinical trials. Overestimation of the effect size and event rate can lead to inadequately powered studies and increased probability of false negative results. This is common in trials involving critically ill patients. However, such overestimation has not been systematically evaluated in trials involving neurocritical care. We aimed to conduct a systematic review of published randomised clinical trials involving critically ill neurological patients, to determine the accuracy of effect size and event rate estimation.

Methods and analysis

We will review randomised clinical trials involving adult critically ill neurological patients that were published from 2015 onwards in

SUBMITTER: Shrestha GS 

PROVIDER: S-EPMC12742086 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature