Smoking reduction trajectories and their association with smoking cessation: a secondary analysis of longitudinal clinical trial data.

ABSTRACT:

Introduction

Tobacco smoking remains the leading cause of preventable death worldwide. Smoking reduction can be recommended to people unmotivated to quit, but evidence on trajectories of reduction and associated outcomes is mixed.

Methods

In a secondary analysis of five randomised, placebo-controlled trials of nicotine replacement therapy, we used latent class analysis and elastic net regression to determine latent smoking trajectories using cigarettes-per-day (CPD) across 26 weeks. Participants were adults who smoked daily without intention to quit in the next month. We used predictive modelling and receiver operator characteristic area under-the-curve (AUC) to assess smoking cessation after 1 year.

Results

Participants (n=2066) smoked a mean 27.26±9.74 CPD at baseli

SUBMITTER: Barrows A 

PROVIDER: S-EPMC12742168 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature