Prophylaxis for venous thromboembolism in traumatic brain injury: protocol for a randomised controlled trial.

ABSTRACT:

Introduction

Venous thromboembolism (VTE) is a common complication of traumatic brain injury (TBI) and is associated with increased morbidity and mortality. Low molecular weight heparin (LMWH) is recommended for prophylaxis against VTE after trauma but may increase the risk of progression of intracranial bleeding. Limited evidence exists to guide clinicians regarding the optimal timing of VTE prophylaxis in patients with acute TBI. This randomised controlled trial (RCT) will directly compare the safety and effectiveness of early versus delayed initiation of LMWH in patients with moderate to severe TBI.

Methods and analysis

The study design is a Bayesian adaptive RCT comparing early (within three calendar days of injury) versus delayed (after study Day 7) VTE prophylaxis with

SUBMITTER: Pirouzmand F 

PROVIDER: S-EPMC12742180 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature