Mutation patterns and prognostic potentiality of homologous recombination repair genes in gliomas.

ABSTRACT: Gliomas are primary malignant brain tumors with poor prognosis. Conventional therapies have achieved limited improvements, and there is an urgent need for new treatments. Homologous recombination repair (HRR) defects are observed in many types of cancer and confer increased sensitivity to platinum-based chemotherapies and poly-ADP ribose polymerase (PARP) inhibitors. To our knowledge, HRR mutations in gliomas have not been extensively reported. To this end, we analyzed alterations in 39 HRR related genes and divided patients with glioma into different groups according to HRR LOF mutation status. We then analyzed the differences in genetic mutation landscape, TMB, CNV burden, prognosis, and immune-related features between the HRR-LOF group and the NonHRR-LOF group. The results demonstrated

SUBMITTER: Bai H 

PROVIDER: S-EPMC12742194 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature