BRI shows stronger association than BMI for MACE in patients with T2DM: insights from the ACCORD study.

ABSTRACT:

Objective

This study investigated the associations of the body roundness index (BRI) with major adverse cardiovascular events (MACEs, including non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death) and total mortality (TM) in patients with type 2 diabetes mellitus (T2DM) from the ACCORD/ACCORDION cohort.

Methods

During a median follow-up of 8.82 years, a total of 1,802 participants (17.76%) experienced MACEs, and 1,926 participants (18.98%) died from all causes. We used Cox proportional hazards regression models to evaluate the association of BRI and body mass index (BMI) with MACEs and TM. Non-linear dynamics between BRI and these outcomes were probed via restricted cubic spline and smooth curve-fitting, identifying pivotal risk thresholds. Comprehens

SUBMITTER: Liu M 

PROVIDER: S-EPMC12742206 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature