Gut-lung axis in allergic rhinitis: microbial dysbiosis and therapeutic strategies.

ABSTRACT:

Background

Allergic rhinitis (AR) affects an estimated 10%-30% of people worldwide and places a significant burden on both health and healthcare systems. Recent research suggests that imbalances in the gut microbiota may contribute to the development of AR by disrupting immune regulation along the gut-lung axis. However, these insights have yet to be fully translated into clinical practice.

Methods

We performed a systematic review of studies published between 2010 and 2025, including clinical research, animal experiments, and multi-omics analyses, retrieved from PubMed, Web of Science, Embase, Cochrane, CNKI, and Wanfang databases. The review aimed to evaluate immune mechanisms mediated by the gut microbiota and assess microbiota-targeted interventions in AR.

Results

SUBMITTER: Yang W 

PROVIDER: S-EPMC12742311 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature