HtSNPer1.0: software for haplotype block partition and htSNPs selection.

ABSTRACT:

Background

There is recently great interest in haplotype block structure and haplotype tagging SNPs (htSNPs) in the human genome for its implication on htSNPs-based association mapping strategy for complex disease. Different definitions have been used to characterize the haplotype block structure in the human genome, and several different performance criteria and algorithms have been suggested on htSNPs selection.

Results

A heuristic algorithm, generalized branch-and-bound algorithm, is applied to the searching of minimal set of haplotype tagging SNPs (htSNPs) according to different htSNPs performance criteria. We develop a software htSNPer1.0 to implement the algorithm, and integrate three htSNPs performance criteria and four haplotype block definitions for haplotype block

SUBMITTER: Ding K 

PROVIDER: S-EPMC1274247 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature