Combining Affymetrix microarray results.

ABSTRACT:

Background

As the use of microarray technology becomes more prevalent it is not unusual to find several laboratories employing the same microarray technology to identify genes related to the same condition in the same species. Although the experimental specifics are similar, typically a different list of statistically significant genes result from each data analysis.

Results

We propose a statistically-based meta-analytic approach to microarray analysis for the purpose of systematically combining results from the different laboratories. This approach provides a more precise view of genes that are significantly related to the condition of interest while simultaneously allowing for differences between laboratories. Of particular interest is the widely used Affymetrix oligonucle

SUBMITTER: Stevens JR 

PROVIDER: S-EPMC1274254 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature