Prognostic Factors and Nomogram-Based Prediction Models for Colorectal Cancer Patients With Synchronous Peritoneal Metastasis Undergoing Cytoreductive Surgery: A Retrospective Cohort Study.

ABSTRACT:

Background

Colorectal cancer (CRC) with synchronous peritoneal metastasis (SPM) presents poor prognosis and complex treatment challenges. This study aimed to identify independent prognostic factors and develop nomogram-based prediction models for overall survival (OS) and progression-free survival (PFS) in CRC patients with SPM (CRC-SPM) undergoing cytoreductive surgery (CRS).

Methods

We retrospectively analyzed 218 CRC-SPM treated with CRS between October 2010 and April 2022. Univariate and multivariate Cox regression analyses were used to identify independent prognostic factors for OS and PFS. Nomogram models were constructed based on these factors, and their predictive accuracy was assessed using calibration curves, ROC curves, and Decision Curve Analysis (DCA).

Result

SUBMITTER: Ge X 

PROVIDER: S-EPMC12742547 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature