Informing the Borrowing Process for Dose-Finding Trials by Estimating the Similarity Between Population-Specific Dose-Toxicity Curves.

ABSTRACT: The conduct of dose-finding trials can be specifically challenging in small populations, for example, in pediatric settings. Recently, research has shown that Bayesian borrowing from adult trials combined with appropriately robust prior distributions enables the conduct of pediatric dose-finding trials with very small sample sizes. However, the appropriate degree of borrowing remains a subjective choice, relying on default methods or expert opinion. This paper proposes an approach to empirically determine the degree of borrowing based on a meta-analysis of the similarity between population-specific dose-toxicity curves of other biologically similar compounds. Focusing on the pediatric use case, the approach may be applicable to any dose-finding trial with information borrowing from another

SUBMITTER: Zocholl D 

PROVIDER: S-EPMC12742552 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature