Predictors of Treatment Adherence in a Randomized Clinical Trial of Digital Therapeutics with Pharmacology for Alcohol Use Disorder (AUD).

ABSTRACT:

Background/aims

Non-adherence is a significant issue in clinical trials of new therapeutics; and Alcohol Use Disorder (AUD) studies are particularly vulnerable to discontinuation. Moreover, clinical trials involving behavioral intervention over time may be even more difficult to complete. Digital therapeutics make participation in treatment much more accessible and may therefore reduce one of the barriers to study participation. This study aims to investigate predictors of treatment adherence in a clinical trial that collected data over 13 weeks involving a digital therapeutic Cognitive Remediation Therapy (CRT) and donepezil for patients with AUD, focusing on (1) CRT adherence (total hours completed); (2) medication adherence (pill count) and (3) total adherence that combines 1 an

SUBMITTER: Bell MD 

PROVIDER: S-EPMC12742581 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature