Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes.

ABSTRACT:

Background

The 'lid' subcomplex of the 26S proteasome and the COP9 signalosome (CSN complex) share a common architecture consisting of six subunits harbouring a so-called PCI domain (proteasome, CSN, eIF3) at their C-terminus, plus two subunits containing MPN domains (Mpr1/Pad1 N-terminal). The translation initiation complex eIF3 also contains PCI- and MPN-domain proteins, but seems to deviate from the 6+2 stoichiometry. Initially, the PCI domain was defined as the region of detectable sequence similarity between the components mentioned above.

Results

During an exhaustive bioinformatical analysis of proteasome components, we detected multiple instances of tetratrico-peptide repeats (TPR) in the N-terminal region of most PCI proteins, suggesting that their homology is not re

SUBMITTER: Scheel H 

PROVIDER: S-EPMC1274264 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature