Genetic association of microRNA-146a polymorphisms with the severity of coronary artery lesions in acute myocardial infarction.

ABSTRACT:

Background

Polymorphisms situated within the microRNA-146a gene have been extensively reported to fulfill a crucial regulatory function in controlling inflammatory responses and modulating gene expression. More recently, these specific genetic variants have also been implicated in the pathogenesis of coronary artery lesions; nevertheless, the current body of available evidence remains notably sparse.

Objectives

To investigate the characteristics of the microRNA-146a gene polymorphisms rs2431697, rs57095329, and rs2910164, and their association with the severity of coronary artery lesions.

Materials and methods

This comparative cross-sectional study included patients with acute myocardial infarction (AMI) and a control group, recruited from two hospitals in Can Tho Cit

SUBMITTER: Ngo TH 

PROVIDER: S-EPMC12742729 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature