A scoping review of interventions to prevent and treat adverse events during treatment of rifampin-susceptible tuberculosis.

ABSTRACT:

Background

Treatment-related adverse events are one of the leading barriers to tuberculosis treatment completion but have not been the focus of late-phase clinical trials. We performed a scoping review to identify interventions to improve the safety and tolerability of rifampin-susceptible tuberculosis. Our objective was to determine what interventions have been evaluated to prevent or manage adverse events, as well as what research is underway.

Methods and findings

We searched Embase, PubMed, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Web of Science from 1970 to December 2024 using a broad set of terms regarding adverse events, as well as citation searches to identify additional studies in topic areas that were not well-repr

SUBMITTER: Burman WJ 

PROVIDER: S-EPMC12742745 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature