The absence or the pharmacological blockade of the aryl hydrocarbon receptor promotes neuroprotection in the hippocampus after an ischemic insult.

ABSTRACT: The aryl hydrocarbon receptor (AhR) is a transcription factor that acts as a nuclear receptor mediating xenobiotic metabolism and environmental responses. Recent evidence suggests that the AhR is implicated in maintaining homeostasis or triggering pathological effects by modulating different physiological responses in the nervous system. However, the underlying mechanisms of the AhR-induced effects in the hippocampus remain unclear. Herein, we report a previously unknown role for the AhR in the pathogenesis of a transient global ischemic insult. Comparative analysis of the expression of HIF-1α, nNOS, iNOS, IL6, KAT II, and claudin 5 in the hippocampus of AhR+/+ and AhR-/- mice after bilateral common carotid artery occlusion revealed differential modulation. We report that AhR-/- mice signi

SUBMITTER: Castaneda-Arellano R 

PROVIDER: S-EPMC12742769 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature