CoaSim: a flexible environment for simulating genetic data under coalescent models.

ABSTRACT:

Background

Coalescent simulations are playing a large role in interpreting large scale intra-specific sequence or polymorphism surveys and for planning and evaluating association studies. Coalescent simulations of data sets under different models can be compared to the actual data to test the importance of different evolutionary factors and thus get insight into these.

Results

We have created the CoaSim application as a flexible environment for Monte Carlo simulation of various types of genetic data under equilibrium and non-equilibrium coalescent processes for a variety of applications. Interaction with the tool is through the Guile version of the Scheme scripting language. Scheme scripts for many standard and advanced applications are provided and these can easily be modif

SUBMITTER: Mailund T 

PROVIDER: S-EPMC1274299 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature