Human promoter genomic composition demonstrates non-random groupings that reflect general cellular function.

ABSTRACT:

Background

The purpose of this study is to determine whether or not there exists nonrandom grouping of cis-regulatory elements within gene promoters that can be perceived independent of gene expression data and whether or not there is any correlation between this grouping and the biological function of the gene.

Results

Using ProSpector, a web-based promoter search and annotation tool, we have applied an unbiased approach to analyze the transcription factor binding site frequencies of 1400 base pair genomic segments positioned at 1200 base pairs upstream and 200 base pairs downstream of the transcriptional start site of 7298 commonly studied human genes. Partitional clustering of the transcription factor binding site composition within these promoter segments reveals a small

SUBMITTER: McNutt MC 

PROVIDER: S-EPMC1274301 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature