Modulation of Brain Temporal Complexity During Treatment for Depression: A CAN-BIND-1 Study Report: Modulation de la complexite temporelle du cerveau pendant le traitement de la depression: rapport de l'etude CAN-BIND-1.

ABSTRACT: ObjectivesCurrent pharmacological antidepressant treatments suffer from low remission rates and slow initiation of therapeutic effects. In addition, the development of new antidepressant treatments is confounded by the lack of consensus on efficient and valid neurophysiological targets. Temporal complexity is an alternative measure of dynamic brain activity that estimates brain signal variability at several timescales. It can be easily extracted from non-invasive brain recordings and provides new insights into pathophysiological mechanisms. We aim to assess the potential of brain temporal complexity as a novel neuromarker to predict the effectiveness of antidepressant treatments.MethodWe measured longitudinal changes in temporal complexity of electroencephalography signals in patients unde

SUBMITTER: Stengel C 

PROVIDER: S-EPMC12743011 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature