The key role for local base order in the generation of multiple forms of China HIV-1 B'/C intersubtype recombinants.

ABSTRACT:

Background

HIV-1 is a retrovirus with high rate of recombination. Increasing experimental studies in vitro indicated that local hairpin structure of RNA was associated with recombination by favoring RT pausing and promoting strand transfer. A method to estimate the potential to form stem-loop structure by calculating the folding of randomized sequence difference (FORS-D) has been used to investigate the relationship between secondary structure and evolutionary pressure in some genome. It showed that gene regions under strong positive "Darwinian" selection were associated with positive FORS-D values. In the present study, the sequences of HIV-1 subtypes B' and C, both of which represent the parent strains of CRF07_BC, CRF08_BC and China URFs, were selected to investigate the relatio

SUBMITTER: Zhang CY 

PROVIDER: S-EPMC1274309 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature