Plasma NFL, GFAP, sTREM2, pTau231, and clinical severity in progressive supranuclear palsy.

ABSTRACT:

Objectives

This study aimed to investigate four plasma markers, pTau231, sTREM2, neurofilament light chain (NFL), and glial fibrillary acidic protein (GFAP), in relation to disease severity in a Korean cohort of progressive supranuclear palsy (PSP).

Methods

Baseline data from patients with probable PSP enrolled in the SCANPSP cohort (NCT05579301) were compared with those of age-matched healthy controls (HC). Four plasma markers measured using the Simoa method, clinical findings, and volumetric 3 T MRI were investigated.

Results

This study included 68 patients with PSP and 30 HC. Group level difference were found in NFL, correlating with the PSP-rating scale (r = 0.48, p = 2.0·10^-4) and global cognitive scores (r = -0.34, p = 0.0061 for Mini-Mental Status Ex

SUBMITTER: Lee S 

PROVIDER: S-EPMC12743097 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature