Liensinine can improve vascular remodeling in hypertension through the ferroptosis-related TLR4 inflammatory pathway.

ABSTRACT: Vascular remodeling, which results in aortic sclerosis, is one of the main risk factors for hypertension-related cardiovascular events. In the process of early intervention and clinical improvement, the inhibition of this process is very important. Previous studies have shown that liensinine (Lien) alleviates hypertension-induced vascular remodeling, but its mechanism of action remains unclear. This study aimed to investigate the therapeutic effects of Lien on hypertension, explore its molecular targets, and elucidate its anti-inflammatory mechanisms related to ferroptosis in preventing vascular remodeling. In vivo, Lien significantly reduced blood pressure and PWV and improved vascular pathology by reducing aortic wall thickness in hypertensive mice. The results of the WB experiment indic

SUBMITTER: Chen D 

PROVIDER: S-EPMC12743113 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature