Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL.

ABSTRACT:

Background

Arterial spin labeling (ASL) MRI is a non-invasive perfusion imaging technique with potential for assessing hemodynamics in children. However, understanding hemodynamic changes in developing brains remains challenging. This study investigates the impact of normal brain development on ASL-derived cerebral blood flow (CBF) and arterial transit time (ATT) in MR-negative children.

Methods

Thirty-two pediatric subjects (ages 0.7-17.9 years, mean 9.3 ± 5.3y, 19 male) with MR-negative findings were retrospectively included. Four pseudo-continuous ASL (PCASL) scans were acquired: single-delay (PLD 1525 or 2025 ms) and multi-delay (3 or 7 delays). CBF and ATT in supratentorial gray matter (GM), white matter (WM), and total-brain (TB) regions were analyzed using paired t-te

SUBMITTER: Prysiazhniuk Y 

PROVIDER: S-EPMC12743115 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature