Assessing the power of tag SNPs in the mapping of quantitative trait loci (QTL) with extremal and random samples.

ABSTRACT:

Background

Recent studies have indicated that the human genome could be divided into regions with low haplotype diversity interspersed with regions of high haplotype diversity. In regions of low haplotype diversity, a small fraction of SNPs (tag SNPs) are sufficient to account for most of the haplotype diversity of the human genome. These tag SNPs can be extremely useful for testing the association of a marker locus with a qualitative or quantitative trait locus in that it may not be necessary to genotype all the SNPs. When tag SNPs are used to reduce the genotyping effort in association studies, it is important to know how much power is lost. It is also important to know how much power is gained when tag SNPs instead of the same number of randomly chosen SNPs are used.

Results<

SUBMITTER: Zhang K 

PROVIDER: S-EPMC1274312 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature