Differential expression of miRNAs in primary canine appendicular osteosarcoma tissue and pulmonary metastases.

ABSTRACT: Canine appendicular osteosarcoma (OSA) is a highly metastatic tumor in dogs. Mortality due to metastatic disease is common and frequently occurs within 1 year of diagnosis despite standard-of-care treatment. Treatment includes amputation for palliation and chemotherapy for metastatic disease. Current histologic grading schemes and biomarkers are poor at predicting clinical outcome. Novel prognostic and therapeutic markers are required to improve patient care. MicroRNAs (miRNAs) are small molecules expressed by all cells and released into bodily fluids. Studies in human and canine OSA cell lines, tissues from the primary site, and blood have demonstrated the role of miRNAs in metastatic progression of OSA and its prognostication. We sought to investigate the miRNA profile of primary OSA tis

SUBMITTER: Ludwig L 

PROVIDER: S-EPMC12743129 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature